目的探讨吉林省先天梅毒儿童现状及相关影响因素。方法采用病例对照研究方法对先天梅毒儿童的相关因素暴露情况进行分析,并运用Logistic回归的统计方法进行多因素分析,校正混杂因素。结果单因素分析有统计学意义的变量包括:母亲诊断梅毒的滴度、母亲孕产期异常情况、孕产妇抗梅毒药物应用情况、儿童出生体重。多因素分析显示母亲诊断梅毒的滴度较高、孕产期发生异常情况是儿童感染先天梅毒的危险因素,母亲进行抗梅毒治疗、儿童出生体重较高是儿童感染先天梅毒的保护因素。结论母亲非梅毒螺旋体检测试验滴度高、孕产期发生异常情况、母亲未进行抗梅毒治疗、出生体重低的儿童发生先天梅毒的可能性较大。

Objective To discuss the status and influencing factors of childrenwith congenital syphilis in Jilin. Methods A casecontrol study was used analyzed the exposure of related factors in children with congenital syphilis. Logistic regression was used to analyze the influencing factors of children with congenital syphilis to correct the confounding factors. Results Unvarable analysis showed there were statistical differences in the titer of RPR and abnormal conditions and antisyphilic medicine of pregnancy and the birth weight of newborns between the two groups( P < 0. 05). Multivarable analysis showed the risk factors of congenital syphilis including high titer of RPR and abnormal conditions of pregnancy. Anti-syphilic medicine of pregnancy and higher birth weight of newborns were protective factors. Conclusion The risk of congenital syphilis is high for children if the mother had high titer of RPR and abnormal conditions of pregnancy and if not had anti-syphilic medicine of pregnancy and low birth weight of newborns. Children whose mothers with high titer of RPR,abnormal conditions during pregnancy and parturition,without anti-syphilis treatment and children with low birth weight are more likely to develop congenital syphilis.