目的 了解广东省2023年35～64岁妇女乳腺癌筛查情况及空间聚集性特征，为广东省乳腺癌防控工作提供科学依据。方法 通过2023年广东省妇女乳腺癌筛查情况年报表获取广东省21个地市乳腺癌人群筛查率、乳腺癌检出率、乳腺癌早诊率和乳腺癌治疗率，应用SPSS 25.0软件对该数据进行描述性统计分析，应用Arc GIS Pro 3.0软件对该数据进行空间自相关分析与热点分析。结果 2023年广东省乳腺癌人群筛查率为53.48%，乳腺癌检出率为128.00/10万，早诊率为68.39%，治疗率为96.91%。广东省适龄妇女乳腺癌人群筛查率呈现聚集分布特征（全局Monran’s I值=0.616,P <0.001），全省乳腺癌早诊率、乳腺癌检出率及治疗率不具有全局空间自相关性。局部空间自相关性结果显示，广州市乳腺癌筛查率呈现高值-高值聚类，乳腺癌检出率呈现低值-低值聚类。适龄妇女乳腺癌人群筛查率的热点区域主要集中在珠三角地区（广州市、佛山市、东莞市、中山市、深圳市及珠海市），冷点区域主要集中在粤东地区（揭阳市、汕头市及汕尾市），乳腺癌早诊率、乳腺癌检出率、乳腺癌治疗率冷点区域及热点区域不显著。结论 广东省珠三角地区乳腺癌人群筛查率高而乳腺癌检出率低，粤东、粤西地区乳腺癌人群筛查率低而乳腺癌检出率高的地理模式差异应得以重视。广东省不同区域有必要进一步分析乳腺癌人群筛查率的影响因素，为制定更有针对性的区域乳腺癌防控策略提供科学依据。

Objective To explore status of breast cancer screening and characteristics of spatial aggregation among women aged35-64 years in Guangdong province in 2023, so as to provide scientific evidence for prevention and control of breast cancer in Guangdong. Methods The population screening rate, detection rate, early diagnosis rate and treatment rate of breast cancer in 21cities were retrieved from the annual report of women's cervical and breast cancer screening program in Guangdong province in 2023descriptive statistics was conducted through SPSS 25.0, and spatial autocorrelation and hotspot analysis was conducted through Arc GIS Pro 3.0 software. Results In 2023, the population screening rate, detection rate, early diagnosis rate, and treatment rate of breast cancer in Guangdong province were 53.48%, 128/100 000, 68.39%, and 96.91%, respectively. The population screening rate of breast cancer in Guangdong province among women of the appropriate age group showed the characteristics of clustered distribution(global Monran's I value = 0.616, P < 0.001), but no significant globally spatial autocorrelation was observed in the provincial early diagnosis rate, detection rate, and treatment rate. The results of local spatial autocorrelation disclosed that the screening rate of breast cancer in Guangzhou city showed high value-high value clustering while the detection rate of breast cancer showed low value-low value clustering. The hot spots of breast cancer screening among women of the appropriate age were mainly concentrated in the Pearl River Delta region(Guangzhou, Foshan, Dongguan, Zhongshan, Shenzhen, and Zhuhai city), while the cold spots were mainly concentrated in the eastern part of Guangdong Province(Jieyang, Shangtou and Shanwei city). There were no difference between cold spots and hot spots in terms of breast cancer early diagnosis rate, detection rate, and treatment rate. Conclusion The geographical disparity in breast cancer screening and detection rate across Guangdong province warrants greater attention—specifically, the Pearl River Delta region exhibits high screening rate but low detection rate, while eastern and western Guangdong show the opposite pattern with low screening rate but high detection rate. Further analysis on the factors associated with population-based breast cancer screening rates in different regions of Guangdong should be conducted so as to provide scientific evidence for formulating more targeted regional breast cancer prevention and control strategies.