目的评价孕前优生检查和健康教育对出生缺陷干预的效果。方法通过计算机检索中国(CNKI)学术文献总库、万方数据知识服务平台、中文科技期刊数据库和中国生物医学文献数据库和人工检索的方式,收集2000-2014年公开发表的关于孕前优生检查和健康教育对出生缺陷干预的文章。对符合纳入标准的文章,应用Meta分析。结果最后符合纳入标准的文献共7篇,具有同质性,采用固定效应模型,效应合并值的假设检验Z=5.15,P<0.000 01,合并的OR值为0.34,差异有统计学意义。结论观察组出生缺陷率低于对照组,干预有效。

Objective To evaluate the intervention effect of pregnancy eugenics inspection and health education on birth defects.Methods Through the computer retrieval China( CNKI) academic literature pool,the data knowledge service platform of ten thousand,Chinese science and technology periodical database and Chinese biomedical literature database and the way of manual retrieval,papers about pregnancy eugenics inspection and health education of birth defects intervention published from 2000 to 2014 were collected. The papers which accord with the inclusion criteria were analyzed. Results A total of 7 papers accord with the inclusion criteria and homogeneity,fixed effect model was used,the effects of combined value of hypothesis test Z = 5. 15,P <0. 000 01,merger OR value was 0. 34,the difference was statistically significant. Conclusion The incidence of birth defects of observation group was lower than control group,and the intervention was effective.