目的探讨孕妇血清维生素D水平与胎膜早破的相关性。方法将80例胎膜早破孕妇作为观察组,80例非胎膜早破的孕妇作为对照组,并分别按血清25羟维生素D(25OHD)水平分为观察组A(维生素D缺乏与不足组)、观察组B(维生素D正常组)、对照组A(维生素D缺乏与不足组)、对照组B(维生素D正常组),比较各组25OHD水平及生殖道感染指标,并对结果进行统计学分析。结果观察组A的生殖道感染率明显高于观察组B,差异有统计学意义(P<0.05);对照组A的生殖道感染率明显高于对照组B,差异有统计学意义(P<0.05);观察组A的生殖道感染率与对照组A比较,两组差异无统计学意义(P>0.05);观察组的生殖道感染率、维生素D缺乏与不足率均明显高于对照组,差异有统计学意义(P<0.05)。结论孕妇血清维生素D缺乏与不足容易出现生殖道感染,从而增加胎膜早破的发生率,有必要在孕期进行25OHD测定,对维生素D缺乏与不足者通过补充维生素D,减少胎膜早破的发生,从而达到减少母婴并发症,提高生活质量的目标。

Objective To discuss the relationship between serum vitamin D and premature rupture of membranes( PROM).Methods 80 cases of pregnant women with PROM were divided into observation group and 80 cases of pregnant women without PROM divided into control group. And the two groups were also divided into observation group A( vitamin D deficiency and insufficiency),observation group B( vitamin D normal),control group A( vitamin D deficiency and insufficiency) and control group B( vitamin D normal) according to the level of serum 25-hydroxyvitamin D( 25OHD),the level of 25 OHD and reproductive tract infections were analyzed among different groups. Results The rate of reproductive tract infection of observation group A was higher than that of observation group B,the difference was statistically significant( P < 0. 05); the rate of reproductive tract infection of control group A was higher than that of control group B,the difference was statistically significant( P < 0. 05); the differences were not statistically significant between observation group A and control group A in the rate of reproductive tract infection( P > 0. 05); the rate of reproductive tract infection and the rate of vitamin D deficiency and insufficiency in observation group were both higher than those in control group,the difference was statistically significant( P < 0. 05). Conclusion Serum vitamin D deficiency and insufficiency of pregnant women may lead to reproductive tract infections,and increase the incidence of premature rupture of membranes,so it is necessary to determine 25-hydroxyvitamin D during pregnancy; Supplement of vitamin D for those persons of vitamin D deficiency and insufficiency will reduce the occurrence of PROM and complications of mother and infant,improve the quality of life.