目的分析研究极低出生体重儿(VLBWI)和超低出生体重儿(ELBWI)神经发育预后及影响因素。方法回顾性分析聊城市东昌府区妇幼保健院随机选取儿科收治并救活的VLBWI和ELBWI患儿80例,分为神经发育正常组及神经发育损害者各40例,分析可能的影响因素,以及神经发育预后情况。结果 80例患儿平均胎龄(30.0±2.2)周,胎龄28周15例,29~32周40例,>32周25例;出生体重平均为(1207.5±207.4)g,经多因素回归分析,脑损伤是VLBWI和ELBWI患儿神经发育损伤的独立危险因素。使用机械通气患儿的PDI得分低于未用者,两者具有统计学意义(P<0.05)。结论 VLBWI和ELBWI患儿神经发育受损发生率较高,尤其是接受机械通气治疗的患儿。

Objective To analysis neurodevelopmental prognosis and impacting factors of very low birth weight infant( VLBWI)and extremely low birth weight infant( ELBWI). Methods Retrospectively analysis method was used,and 80 cases of VLBWI and ELBWI children treated in our hospital were randomly selected,they were assigned into two groups,with 40 cases in Normal neurodevelopmental group and 40 cases in impaired neurodevelopmental group. The possible impacting factors and neurodevelopmental prognosis were analyzed. Results The average gestational age of the 80 children was( 30. 0 ± 2. 2) weeks,with 15 cases of 28 weeks,40 cases of 29-32 weeks and 25 cases of more than 32 weeks. The average birth weight was( 1207. 5 ± 207. 4) g,cerebral injury was the Independent risk factor for neurodevelopmental impairment of VLBWI and ELBWI by multivariate regression analysis.PDI score of patients using mechanical ventilation was lower than that of patients without using mechanical ventilation,and the difference was statistically significant( P < 0. 05). Conclusion The Incidence of neurodevelopmental impairment among VLBWI and ELBWI children was high,especially on patients received mechanical ventilation.