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2024, 05, v.15 32-37
2019—2023年广东省广州市特应性皮炎儿童过敏原结果分析
基金项目(Foundation): 广东省医学科学技术研究基金(A2021434)
邮箱(Email): jieling3861@163.com;
DOI: 10.19757/j.cnki.issn1674-7763.2024.05.006
摘要:

目的 分析特应性皮炎儿童的过敏原结果,为广东省广州市儿童特应性皮炎的防治提供科学依据。方法 选取2019年1月1日至2023年6月30日于广东省妇幼保健院儿童保健门诊就诊的0~6岁的特应性皮炎儿童为研究对象,采用荧光免疫法检测血清中特异性免疫球蛋白(Immunoglobulin E,IgE)水平,分析过敏原检测阳性率和分布特征。结果 共纳入1 465名特应性皮炎儿童,其中43.2%的特应性皮炎儿童对过敏原呈阳性反应,多过敏原儿童过敏原阳性率(26.4%)比单一过敏原阳性率高(16.8%)。特应性皮炎儿童主要食入性过敏原为牛奶和鸡蛋白,主要吸入性过敏原为尘螨和猫毛。食入性过敏原阳性率在1~2岁儿童中最高(53.8%),在> 2岁儿童中有所下降(46.5%)。吸入性过敏原阳性率随儿童年龄的增长而升高。吸入性过敏原阳性率在夏秋季节略高。结论 广州市特应性皮炎儿童常见过敏原为牛奶、鸡蛋白、尘螨和猫毛。因不同年龄过敏原存在一定差异,因此在进行过敏原检测时,年龄应作为一个重要的参考因素给予重视。

Abstract:

Objective The study focuses on analyzing the distribution and characteristics of allergens in children with atopic dermatitis(AD) in the Guangzhou, with the objective of informing clinical practices and interventions. Methods Analysis was conducted on AD children aged 0 ~ 6 years old who visited the pediatric outpatient clinic of the Guangdong Women and Children Hospital between January 1, 2019, and June 30, 2023. The levels of specific IgE(sIgE) in serum were measured using fluorescence immunoassay. The positive rates and distribution characteristics of allergen testing were analyzed. Results A total of 1 465 children with AD were included in the analysis. 43.2% of AD children showed positive reactions to allergens. Children with multiple allergen positivity had a higher rate than those with single allergen positivity(26.4% v.s.16.8%). The main food allergens were milk and egg white, while the main inhalant allergens were dust mites and cat hair. The distribution of allergens in AD children varied among different age groups, with the highest positive rate of food allergens in children aged 1 to 2 years(53.8%), which decreased in children older than 2 years(46.5%). The positive rate of inhalant allergens significantly increased with age. The positive rates of food and inhalant allergens were slightly higher in the summer and autumn seasons. Conclusion The common allergens in AD children in the Guangzhou are milk, egg white, dust mites, and cat hair. Allergen distribution varies with age. Therefore, age should be considered as an important reference factor in allergen testing.

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基本信息:

DOI:10.19757/j.cnki.issn1674-7763.2024.05.006

中图分类号:R758.2

引用信息:

[1]余莉,柯海劲,龙梓瑜等.2019—2023年广东省广州市特应性皮炎儿童过敏原结果分析[J].中国妇幼卫生杂志,2024,15(05):32-37.DOI:10.19757/j.cnki.issn1674-7763.2024.05.006.

基金信息:

广东省医学科学技术研究基金(A2021434)

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