参考文献

[1]Beck S,Wojdyla D,Say Lale,et al.The worldwide inci-dence of preterm birth:a systematic review of maternal and morbidity[J].Bull world Health Organ,2010,88:31-38.

[2]Hsu SY,Nakabayashi K,Nishi S,et al.Activation of or-phan receptors by the hormone relaxin[J].Science,2002,(295),671-674.

[3]Liu CL,Chen JC,Sutton S,et al.Identification of relaxin-3/INSL7as a ligand for GPCR142[J].J Biol Chem,2003,278:50765-50770.

[4]Schwabe C,McDonald JK.Relaxin:a disulfide homolog of insulin[J].Science,1977,197:914-915.

[5]Bathgate RA,Siebel AL,Tovote P,et al.Purification and characterization of relaxin from the tammar wallaby:bio-activity and expression in corpus luteum[J].Biol Re-prod,2002,67(4):293-300.

[6]Coss D,Jacobs SB,Bender CE,et al.A novel AP-1site is criticalfor maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone[J].J Biol Chem,2004,279(1):152-162.

[7]Zhang Q,Liu SH,Erikson M,et al.Relaxin activates the MAP kinase pathway in human endometrial stromal cells[J].J Cell Bio Chem,2002,85(3):536-544.

[8]Sherwood OD,Crnekovic VE.Development of a homolo-gous radioimmunoassay for rat relaxin[J].Endocrinolo-gy,1979,104:893-897.

[9]Klonisch SH,Seeger S,Huppertz B,et a1.Cellular locali-zation of human relaxi-like factor in the cyclic endometri-um and placenta[J].Mol Hum Reprod,2001,7(4):349-356.

[10]Klonisch T,Bialek J,Radestock Y,et al.Relaxin-like ligand-receptor systems are autocrine/paracrine effectors in tumor cells and modulate cancer progression and tissue invasiveness[J].Adv Exp Med Biol,2007,612:104–118.

[11]Parry LJ,McGuane JT,Gehring HM,et al.Mechanisms of relaxin action in the reproductive tract:studies in the relaxin-deficient(Rlx-/-)mouse[J].Ann N Y Acad Sci,2005,1041:91-103.

[12]Li JY,Cooke PS,Meling DD,et al.The effect of relaxin on cell proliferation in mouse cervix requires estrogen re-ceptorαbinding to estrogen response elements in stromal cells[J].Endocrinology,2010,151(6):2811-2818.

[13]Palejwala S,Stein DE,Weiss G,et al.Relaxin positively regulates matrix metalloproteinase expression in human lower uterine segment fibroblaststs using a tyrosine kinase signaling pathway[J].Endocrinology,2001,142:3405-3413.

[14]Goldsmith LT,Weiss G,Palejwala S,et al.Relaxin regula-tion of endometrial function in the rhesus monkey[J].Proc Natl Acad Sci,2004,101:4685-4689.

[15]Hoffmann UF,Baston DM,Chiao JP,et al.The effect of relaxin on the oxytocin receptor in human uterine smoothmuscle cells[J].Science,2007,138:74-81.

[16]Tseng L,Gao JG,Chen R,et al.Effect of progestin,an-tiprogestin and relaxin on the accumulation of prolactin and insulin-like growth factor-binding protein-1messenger ribonucleic acid in human endometrial stromal cells[J].Biol Reprod,1992,47(3):44l-450.

[17]Vogel I,Thorsen P,Hundborg HH,et al.Prediction of pre-term delivery using changes in serum relaxin in low risk pregnancies[J],Eur J Obstet Gynecol,2006,128:113-118.

[18]Goldsmith LT,Weiss G.Relaxin in human pregnancy[J].Ann NY Sci,2009,1160:130-135.

[19]Anumba DOC,Gelany SEI,Elliott SL,et al.Serum relaxin levels are reduced in pregnant women with a history of re-current miscarriage,and correlate with maternal uterine artery doppler indices in?rst trimester[J].Eur J Obstet Gynecol Reprod Biol,2009,147:41-45.

[20]Vogel I,ThorsenP,Curry A,et al.Biomarkers for the pre-diction of preterm delivery[J].Acta Obstet Gynecol Scand,2005,84(6):516-525.

[21]Vogel I,Salvig JD,Secher NJ,et al.Association between raised S-relaxin during the eighteen gestation week andvery preterm delivery[J].Am J Obstet Gynecol,2001,184(3):390-393.

[22]Petersen LK,Vogel I,Oxlund H,et al.No effects of hu-man relaxin on the active and passive biomechanical properties of isolated cervical specimens from nonpregnant women[J].Eur J Obstet Gynecol Reprod Biol,1997,73(2):183-187.

[23]Petersen LK,Helmig R,Vogle I,et al.Relaxin(hRLX-2)-induced weakening of human fetal membranes in vitro[J].Eur J Obstet Gynecol Reprod Biol,1994,57(2):123-128.

[24]Vogel I,Thorsen P,Armbruster FP,et al.S-relaxin as a predictor of preterm delivery in women with symptoms of preterm labour[J].Br J Obstet Gynecol,2002,109(9):977-982.

[25]庄红梅.血清松弛素和阴道超声测量宫颈长度预测早产的实验研究[D].福州:福建医科大学,2007.

[26]Sandager P,Uldbjerg N,Henriksen TB,et al.Circulating relaxin and cervical length in midpregnancy are independ-ently associated with spontaneous preterm birth[J].Am J Obstet Gynecol,2009,201:169-170.