目的 比较产前筛查高风险与低风险孕产妇的抑郁情况，探索产前筛查对不同时期孕产妇抑郁的影响。方法 选取产前筛查孕产妇924例，按风险的高低分为高风险组和低风险组，其中高风险组孕产妇231例，低风险组孕产妇693例。采用流调中心抑郁自评量表分别在产前筛查前、产前筛查后、孕晚期(≥28周)和产后6周对两组孕产妇抑郁水平进行评估，并在产后6周对两组孕产妇进行妊娠结局的调查。结果 产前筛查孕产妇整体抑郁检出率为18.3%,高风险组检出率为30.5%,低风险组检出率为9.2%。在产前筛查后和产后6周，高风险组的抑郁检出率均高于低风险组(χ²=62.556,P<0.001;χ²=27.389,P<0.001)。在产前筛查前，职业以体力劳动为主是孕产妇发生抑郁的保护因素(OR=0.380,95%CI:0.170～0.850);在产前筛查后，产前筛查高风险是抑郁发生的危险因素(OR=7.302,95%CI:4.019～13.267);在孕晚期，产前筛查前、后有抑郁是抑郁发生的危险因素(OR=12.911,95%CI:4.316～38.622;OR=10.601,95%CI:4.854～23.195);在产后6周，产前筛查高风险、产前筛查后有抑郁和孕晚期有抑郁是抑郁发生的危险因素(OR=3.117,95%CI:1.618～6.003;OR=4.510,95%CI:2.126～9.566;OR=7.999,95%CI:3.306～19.353)。结论 产前筛查高风险孕产妇不良情绪和不良妊娠结局发生率高。应在产前筛查结果出来后和产后6周这2个关键期密切关注孕产妇的心理健康状况，给予针对性的心理干预。

Objective To compare depression among high and low risk pregnant women undergoing prenatal screening, and explore factors associated with depression at different pregnant periods. Methods A total of 924 pregnant women undergoing prenatal screening were recruited, and they were divided into high-risk group(231 cases) and low-risk group(693 cases). Self-rating Depression Scale was used to assess the level of depression before prenatal screening, after prenatal screening, late pregnancy(≥28 weeks) and 6 weeks postpartum. The pregnancy outcomes of the two groups were investigated at 6 weeks postpartum. Results The overall detection rate of depression among pregnant women undergoing prenatal screening was 18.3%, of which 30.5% in high-risk group and 9.2 in low-risk group. Depression detection rates were higher in the high-risk group than those in the low-risk group both after prenatal screening and 6 weeks postpartum(χ²=62.556, P<0.001; χ²=27.389,P<0.001). Before prenatal screening, physical labor was a protective factor for maternal depression(OR=0.380, 95%CI:0.170-0.850); After prenatal screening, high risk of prenatal screening was a risk factor for depression(OR=7.302, 95%CI: 4.019-13.267); At late pregnancy, depression pre-and post-prenatal screening was a risk factor for depression(OR=12.911,95%CI: 4.316-38.622; OR=10.601,95%CI: 4.854-23.195). At 6 weeks postpartum, high risk of prenatal screening, depression after prenatal screening and depression at late pregnancy were risk factors for depression(OR=3.117, 95%CI: 1.618-6.003; OR=4.510, 95%CI: 2.126-9.566; OR=7.999,95%CI:3.306-19.353). Conclusion High risk pregnant women diagnosed by prenatal screening have a high incidence of adverse mood and pregnancy outcomes, and close attention should be paid to their mental health after the results of prenatal screening and at 6 weeks postpartum, and targeted psychological intervention should be given to them.