目的 对山东省青岛市预防梅毒母婴传播工作实施效果进行分析，针对发现的薄弱环节制定措施，为我市持续提升消除母婴传播工作提供科学依据，为其他地市优化消除工作提供参考。方法 本研究基于“国家预防艾滋病、梅毒和乙肝母婴传播管理信息系统”中2017年1月1日—2024年12月31日由山东省青岛市上报的《预防艾滋病、梅毒和乙肝母婴传播工作报表》及《梅毒感染孕产妇及所生婴儿个案登记卡》中的数据，使用SPSS 27.0软件对预防梅毒母婴传播工作措施落实及效果进行分析。结果 2017—2024年青岛市产妇梅毒检测率近100.00%(713 974/713 978)，梅毒感染2 059例，阳性率为0.29%，呈上升趋势。本次妊娠孕期确诊1 880例，孕早期确诊占比由13.66%上升至58.30%。梅毒感染产妇中治疗人数为1 781例，充分治疗人数为1 507例，治疗率和充分治疗率分别由64.60%和47.83%提升至99.61%和90.73%。梅毒暴露儿童2 072例，1 595例接受了预防性治疗，预防性治疗率由50.16%上升至99.24%；累计报告先天梅毒9例，报告发病率为1.25/10万活产；2021—2024年报告先天梅毒与感染孕产妇分娩的20周以上死胎、死产16例，先天梅毒发病率为5.80/10万活产。结论 2017—2024年青岛市预防梅毒母婴传播工作取得了良好成效，但仍需提高孕早期检测率和确诊率，提升感染孕产妇充分治疗率，降低先天梅毒发病率。

Objective To analyze the effectiveness of syphilis mother-to-child transmission(MTCT) prevention measures in Qingdao, identify existing challenges, and formulate targeted countermeasures. This aims to provide a scientific basis for improving the quality of syphilis MTCT prevention work in Qingdao and a reference for other regions. Methods Data were extracted from China's National HIV, Syphilis, and Hepatitis B Mother-to-Child Transmission Prevention Management Information System, and Case Registration Records of Syphilis-infected Pregnant Women and Their Infants in Qingdao city, Shandong province, from January 1,2017, to December 31, 2024. SPSS 27.0 software was used to analyze the implementation and effectiveness of syphilis MTCT prevention measures. Results From 2017 to 2024, the syphilis screening rate among pregnant women in Qingdao was nearly 100.00%(713 974/713 978). A total of 2 059 syphilis-positive pregnant women were identified, with a positive rate of 0.29%, showing an annual upward trend. Among these, 1 880 cases were confirmed during the pregnancy, and the proportion of confirmation in the first trimester increased from 13.66% to 58.30%. The treatment rate of syphilis-infected pregnant women increased from 64.60% to 99.61%, and the adequate treatment rate increased from 47.83% to 90.73%. Among 2 072 syphilis-exposed infants, 1 595 received prophylactic treatment, with the prophylactic treatment rate increasing from 50.16% to 99.24%. A total of 9 cases of congenital syphilis were reported, with an incidence rate of 1.25 per 100 000 live births. From 2021 to 2024, 16 cases were reported, including congenital syphilis and stillbirths or fetal deaths after 20 weeks of gestation among infants born to syphilis-infected pregnant women, with an incidence rate of 5.80 per 100 000 live births. Conclusion Qingdao city has achieved significant results in syphilis MTCT prevention from 2017 to 2024. However, it is necessary to continue to improve the early pregnancy screening rate and early pregnancy confirmation rate. In addition, the relatively low adequate treatment rate among syphilis-positive pregnant women and the persistently high incidence of congenital syphilis indicate that further targeted interventions are required.