| 1,062 | 16 | 266 |
| 下载次数 | 被引频次 | 阅读次数 |
女性阴道微生态环境的平衡对于女性生殖健康有重要意义,这种平衡一旦被打破,正常阴道微生态环境将发生改变,从而导致各种阴道感染性疾病的发生,严重时会导致恶性肿瘤。因此,明确阴道菌群及阴道内环境与妇科疾病的关系十分重要,但目前对于阴道微生态环境与各种妇科疾病的确切关系尚缺乏大量可靠数据,有待进一步研究。本文就健康女性阴道微生态菌群、阴道微生态评估手段,以及不同人群阴道微生态情况的最新研究进展进行综述。
Abstract：The balance of female vagina microecological environment is significant to the women's reproductive health.If the balance is broken,the normal vaginal microecological environment will be changed,which would lead to various vaginal infection.It even would lead to serious malignant tumor.Therefore,it is very important to make clear the relationship of vaginal flora and vaginal environment with gynecological diseases.However,at present,there is still lack of a large number of reliable data to support the exact relationship between the vaginal microenvironment and various gynecological diseases.Therefore,it is necessary to do further study.This paper will review the latest research development of the vaginal microecological bacteria of healthy women,vaginal microecological assessment method and different people vaginal microecological condition.
[1]马薇,金措.女性一生不同阶段阴道微生态菌群特征研究进展[J].中国实用妇科与产科杂志,2016(08):817-820.
[2]田小英,廖秦平.阴道微生态与妇科肿瘤的研究[J].中国微生态学杂志,2013,25(07):866-867+869.
[3]Hyman RW,Fukushima M,Diamond L,et al.Microbes on the human vaginal epithelium[J].Proc Natl Sci USA,2005,22(2):7952-7957.
[4]乔金凤.正确评价阴道微生态对阴道炎治疗的重要意义[J].大家健康(学术版),2014(13):22-23.
[5]肖冰冰,刘朝晖.阴道微生态评价在阴道炎中的应用[J].中国妇产科临床杂志,2016(06):483-485.
[6]陈秀红,周红霞.阴道清洁度与念珠菌阳性率的关系[J].中国医学创新,2013,10(5):155-156.
[7]谢芳,锁丙荣.阴道清洁度分级与阴道生态环境的相关性分析[J].河北医药,2013(20):3112-3113.
[8]陈婉珍,闫颖,吴林玲.妊娠期妇女阴道微生态研究进展[J].中国微生态学杂志,2016(04):489-492+497.
[9]廖秦平,吴文湘.女性阴道微生态评价体系的临床应用[J].中国妇产科临床杂志,2010(03):163-164.
[10]Nugent RP,Krohn MA,Hillier SL.Reliability of diagnosing bacterial vaginosis is improved by a standardized method of Gram stain interpretation[J].J Clin Microbiol,1991,29:297-301.
[11]张咏梅,阿丽萍,王晓玲,等.细菌性阴道病患者阴道微生态情况研究[J].宁夏医学杂志,2016(06):560-562.
[12]叶称连,傅芬,陈进聪,等.细菌性阴道病患者宫颈及阴道菌群多样性的比较与分析[J].临床检验杂志,2015(03):200-203.
[13]Chooruk A,Utto P,Teanpaisan R,et al.Prevalence of lactobacilliin norrnal women and women with bacterial vaginosis[J].J Med Assoc Thai,2013,696(5):519-522.
[14]吴文湘,冯佳,廖秦平.重度外阴阴道假丝酵母菌病阴道微生态分析[J].中国实用妇科与产科杂志.2012,28(02):134-136.
[15]王岩,曹敬荣,闵嵘,等.假丝酵母菌性阴道炎患者阴道微生态环境与真菌药敏分析[J].中华实验和临床感染病杂志(电子版),2015(06):94-97.
[16]廖琪,岳新爱,彭英,等.VVC患者与健康育龄妇女的阴道微生态比较[J].现代临床医学,2015,41(06):423-425.
[17]谢幸,苟文丽.妇产科学.8版[M].北京:人民卫生出版社,2013.
[18]易英,曲立兵.滴虫性阴道炎阴道菌群的定性和定量研究[J].中国公共卫生,1999,(11):54-55.
[19]华绍芳,薛凤霞.滴虫性阴道炎的研究进展[J].国外医学.妇产科学分册,2006(05):360-363.
[20]Tansarli GS,Kostaras EK,Athanasiou S,et al.Prevalence and treatment of aerobic vaginitis among non-pregnant women:evaluation of the evidence for an underestimated clinical entity[J].Eur J Clin Microbiol Infect Dis,2013,32(8):977-984.
[21]尹璐瑶,祝洪澜,彭二玄,等.需氧菌性阴道炎临床微生态研究及治疗效果的探讨[J].中国妇产科临床杂志,2014(05):417-421.
[22]逯彩虹,李保红,李小斌,等.宫颈癌患者阴道微生物的分布特点[J].中国医科大学学报,2011,(03):267-271.
[23]Mitra A,Mac Intyre DA,Lee YS,et al.Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity[J].Sci Rep,2015,5:16865-16875.
[24]覃烨,王红丽,任彤.宫颈癌及宫颈上皮内瘤病变与生殖道感染的相关性研究[J].中华医院感染学杂志,2014(04):811-813.
[25]邓晓娥,王蔚蓝,司建英,等.高危型人乳头状瘤病毒导致宫颈癌的临床病理研究[J].中华医院感染学杂志,2014(05):1057-1058+1069.
[26]Clarke MA,Rodriguez AC,Gage JC,et al.A large,population-based study of age-related associations between vaginal p H and human papillomavirus infection[J].BMC Infect Dis,2012,12:33.
[27]Siddiqa A,Zainab M,Qadri I,et al.Prevalence and genotyping of high risk human papillomavirus in cervical cancer samples from Punjab,Pakistan[J].Viruses,2014,6(7):2762-2777.
[28]章亚文,蔡芸.宫颈癌患者的病原菌分布分析[J].中国临床药理学杂志,2015(11):957-959.
[29]Champer M,Wong A M,Champer J,et al.The role of the vaginal microbiome in gynecological cancer:a review[J].Bjog An International Journal of Obstetrics&Gynaecology,2017.
[30]Gao W,Weng J,Gao Y,et al.Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection:a cross-sectional study[J].BMC Infect Dis,2013,13:271.
[31]李东燕,郝敏.阴道微生态平衡与高危型HPV感染分析[J].中国微生态学杂志,2016(05):594-597.
[32]王宝晨,夏玉洁,王辰,等.高危型人乳头瘤病毒感染子宫颈上皮内瘤变患者阴道微生态分析[J].中国妇产科临床杂志,2016(06):486-489.
[33]努尔比亚·阿布拉,姚丽艳.生殖道HPV与其它病原体感染关系的探讨[J].中华全科医学,2014(06):942-944+946.
[34]Gillet E,Meys JF,Verstraelen H,et al.Bacterial vaginosis is associated with uterine cervical human papillomavirus infection:a metaanalysis[J].BMC Infect Dis,2011,11:10.
[35]Verteramo R,Pierangeli A,Mancini E,et al.Human papillomaviruses and genital co-infections in gynaecological outpatients[J].BMC Infect Dis,2009,9:16.
[36]Ghosh I,Mandal R,Kundu P,et al.Association of genital infections other than human papillomavirus with preinvasive and invasive cervical neoplasia[J].J Clin Diagn Res,2016,10:XE01-XE06.
[37]崔丽阳,岳天孚.HR-HPV感染与其他女性生殖道感染因素的关系研究[J].中国妇幼保健,2014(03):352-354.
基本信息:
DOI：10.19757/j.cnki.issn1674-7763.2017.06.020
中图分类号:R711
引用信息:
[1]林琳,高碧燕,杞朝梅.阴道微生态环境的临床研究进展[J].中国妇幼卫生杂志,2017,8(06):71-75.DOI:10.19757/j.cnki.issn1674-7763.2017.06.020.