目的 探究在真实世界中，国家政策推动下形成的“一站式”新型服务管理模式对乙型肝炎病毒（以下简称乙肝）感染孕产妇及其所生新生儿规范诊疗效果的影响，以验证政策效果，提供实践参考，并为进一步优化服务流程、提升诊疗质量提供依据。方法 利用江苏省无锡市妇幼保健院2022年6月1日—2024年5月31日乙肝感染孕产妇及其所生新生儿个案卡数据进行分析。国家政策导向下建立的“一站式”新型服务管理模式主要体现为母婴阻断关爱门诊的开设。通过利用孕妇乙肝脱氧核糖核酸（deoxyribo nucleic acid,DNA）检测孕周、抗病毒规范治疗孕周、新生儿乙肝疫苗接种时间间隔、新生儿免疫球蛋白接种时间间隔、乙肝个案信息填报时间间隔以及孕妇孕期规范接受抗病毒治疗等指标来评估规范诊疗的效果。采用线性回归和二分类logistic回归分别分析母婴阻断关爱门诊开设与否和上述因变量之间的关系。结果 关爱门诊的开设与乙肝病毒DNA检测孕周（β=-7.10, 95%CI:-8.6 8～-5.51, P<0.001）、抗病毒规范治疗孕周（β=-5.17, 95%CI:-8.86～-1.48, P=0.006）、乙肝疫苗接种时间间隔（β=-1.43, 95%CI:-1.68～-1.19, P<0.001）、乙肝免疫球蛋白接种时间间隔（β=-1.60, 95%CI:-1.81～-1.38, P<0.001）、乙肝个案信息填报时间间隔（β=-1.62, 95%CI:-2.39～-0.84, P<0.001）呈负相关。关爱门诊的开设是孕妇孕期规范使用抗病毒药物治疗的保护因素（OR=1.96, 95%CI:1.16～3.29, P=0.011）。结论 在国家新政策指导下，构建“一站式”新型服务管理模式有助于进一步提高乙肝感染孕产妇及其所生新生儿的规范诊疗水平。

Objective This study aimed to evaluate the the real-world impact of a national policy-driven “One-Stop” innovative service management model onstandardized diagnosis and treatment outcomes for hepatitis B virus(HBV)-infected pregnant women and their newborns. The objectives were to verify policy effectiveness and lay a foundation for further optimizing service processes and improving the quality of diagnosis and treatment. Methods Data were analyzed from collated individual case records of HBVinfected pregnant women and their newborns at Wuxi Maternal and Child Health Care Hospital, Jiangsu Province, from June 1 2022, to May 31, 2024. The “One-Stop” new service management model, guided by the national policies, was primarily implemented through the setup of a Mother-to-Child Transmission Prevention(MCTP) care clinic. The effectiveness of standardized diagnosis and treatment was evaluated by using indicators such as the gestational week determined by HBV DNA testing in pregnant women, the gestational week of standardized antiviral therapy, the time intervals for newborn HBV vaccination and immunoglobulin administration, and the reporting time intervals for hepatitis B case information, as well as the standardized antiviral treatment received by pregnant women during pregnancy. Linear regression and binary logistic regression were used to examine the relationships between the establishment of the mother-infant blocking care clinic and the aforementioned dependent variables. Results The establishment of MCTP care clinics exhibited negative correlations with gestational week for hepatitis B virus DNA testing(β =-7.10, 95% CI:-8.68 to-5.51, P < 0.001),gestational week for standardized antiviral treatment(β =-5.17, 95% CI:-8.86 to-1.48, P = 0.006), interval of neonatal HBV vaccine administration(β =-1.43, 95% CI:-1.68 to-1.19, P < 0.001), interval of neonatal hepatitis B immunoglobulin administration(β =-1.60, 95% CI:-1.81 to-1.38, P < 0.001), and interval of hepatitis B case reporting(β =-1.62, 95% CI:-2.39 to-0.84, P < 0.001).Additionally, the establishment of care clinics was a protective factor for pregnant women receiving standardized antiviral drug treatment(OR = 1.96, 95% CI: 1.16 to 3.29, P = 0.011). Conclusion The establishment of a “ One-Stop” innovative service management model guided by national policiy can significantly improve the standardized diagnosis and treatment for HBV-infected pregnant women and their newborns.