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目的系统评价乳酸杆菌预防啮齿动物高脂血症的干预效果。方法基于Pubmed、Embase等文献数据库,检索建库至2018年6月底符合入选与排除标准的各类乳酸杆菌预防啮齿动物高脂血症的随机对照研究,提取有效数据,进行网络Meta分析。结果乳酸杆菌对高脂血症的预防作用的纳入研究Meta分析结果显示:在TC指标森林图中L. casei(RR=-56,95%CI=-1. 1e+02,-7)及LDL指标森林图中L. plantarum(RR=-46,95%CI=-87,-25)、L. acidophilus (RR=-41,95%CI=-67,-14)的95%CI横线与无效竖线不相交,其他的都与无效线相交。结论乳酸杆菌可以预防高脂血症形成,L. rhamnous可以显著降低TC、LDL水平,L. casei可以显著降低TG及升高HDL水平。
Abstract：Objective To systematically evaluate the efficacy of lactobacillus in preventing hyperlipidemia in rodents. Methods Based on Pubmed,Embase and other literature databases,a randomized controlled study on the prevention of hyperlipidemia in rodent by lactobacillus of various types that met the inclusion and exclusion criteria was searched until the end of June 2018 to extract effective data for online meta analysis. Results Meta analysis of the preventive effect of lactobacillus on hyperlipidemia showed that the 95%CI lines of L. casei( RR =-56,95% CI =-1. 1 e + 02,-7),L. plantarum( RR =-46,95% CI =-87,-25) and L. acidophilus( RR =-41,95% CI =-67,-14) in the TC index forest map did not intersect with the invalid vertical line,and the others all intersect with the invalid line. Conclusion Lactobacillus can prevent the formation of hyperlipidemia. L. rhamnous can significantly reduce TC and LDL level,and L. casei can significantly reduce TG and increase HDL level.
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基本信息:
DOI：10.19757/j.cnki.issn1674-7763.2019.02.010
中图分类号:R589.2
引用信息:
[1]牟菲,纪泽敏,陈姝琴,等.乳酸杆菌预防啮齿动物高脂血症的网络Meta分析[J].中国妇幼卫生杂志,2019,10(02):46-50.DOI:10.19757/j.cnki.issn1674-7763.2019.02.010.