| 198 | 4 | 7 |
| 下载次数 | 被引频次 | 阅读次数 |
目的分析广东省常见21种出生缺陷发生率及趋势,为出生缺陷防控工作提供基础参考数据。方法利用2012-2016年广东省58家医院出生缺陷监测数据,选择21种常见且围产期易于明确诊断的出生缺陷病种,计算各病种全省平均发生率,估算各病种全省患儿数。结果所选21个出生缺陷病种5年累计平均发生率为104. 52/万(13 257/1 268 424),出生缺陷患儿中活产占68. 01%(9016/13 257)。2012-2016年,估算全省21种出生缺陷的累计患儿数96 758例[95%CI (96 447,96 758)],年总发生率(/万)分别为106. 56、98. 70、105. 50、105. 83和105. 76,呈现平稳趋势(χ2=0. 795,P=0. 373)。单病种发生率差异巨大,其中腭裂、尿道下裂、并指(趾)、多指(趾)和马蹄内翻足的发生率呈上升趋势,无脑畸形、脊柱裂、脑膨出、先天性脑积水、唇裂、唇腭裂、四肢短缩、脐膨出和腹裂的发生率呈上升趋势。结论广东省出生缺陷疾病负担重,干预措施初见成效。
Abstract：Objective To analysis the prevalence and tendency of 21 frequently types of birth defects in Guangdong province,and provide basic evidence for prevention of birth defects. Methods The data of 58 birth defects surveillance hospitals in Guangdong was used. 21 types of birth defects which easy to be confirmed diagnose during perinatal period were selected. The mean prevalence was calculated and the total number of each selected birth defect of overall province was estimated.. Results The five years mean cumulative prevalence of selected 21 birth defects was 104. 52 per 10 000 births( 13 257/1 268 424),and 68. 01%( 9016/13 257)of them were live birth. The estimated total number of selected 21 birth defects was 96 758 [95% CI( 96 447,96 758) ] from 2012 to 2016 in Guangdong,and the annual total prevalence was 106. 56,98. 70,105. 50,105. 83 and 105. 76 per 10 000 births,respectively. The tendency was stable( χ2= 0. 795,P = 0. 373). The specific prevalence of each birth defect varies greatly. The prevalence of of cleft palate,hypospadia,ankylodactyly,hyperdactylia,and equinovarus showed an increasing tendency. The prevalence of anencephaly,cleft spine,cenencephalocele,congenital hydrocephalus,cleft lip,cleft lip with plate,limbs crispation,acromphalus,and abdominal cleft showed a decreasing tendency. Conclusion In Guangdong,there is a heavy burden of birth defects,and the interventions on birth defects shows initial effects.
[1] Samantha E Parker,Cara T Mai,Mark A Canfield,et al. Updated National Birth Prevalence Estimates for Selected Birth Defects in the United States,2004–2006[J]. Birth Defects Research(Part A),2010,88:1008-1016.
[2] Sun G,Xu ZM,Liang JF,et al. Twelve-year prevalence of common neonatal congenital malformations in Zhejiang Province,China[J]. World J Pediatr,2011,7(4):331-336.
[3] Xiao WL,Zhang DZ,Xu YX. The caries prevalence of oral clefts in eastern China[J]. Int J Clin Exp Med,2015,8(9):16322-16327.
[4] Rudan I,Chan KY,Zhang JS. Causes of deaths in children younger than 5 years in China in 2008[J]. Lancet,2010,375(9720):1083-1089.
[5] Zhang W,Chen D,Xu Y,et al. Mortality Rate for Children under 5 Years of Age in Zhejiang Province,China from 1997 to 2012[J]. PLo S ONE,2015,10(6):e0127770.
[6] Yang M,Zhang S,Du Y. Epidemiology characteristics of birth defects in Shenzhen city during 2003 to 2009,China[J]. J Matern Fetal Neonatal Med,2015,28(7):799-803.
[7] Ministry of Health of People’s Republic of China:Report on Women and Children’s Health Development in China(2011). www. gov. cn/gzdt/2011-09/21/content_1952953. htm.
[8]李兵,张小庄,叶宁,等.广东省1997-2007年医院监测出生缺陷趋势分析[J].中华流行病学杂志,2008,29(11):1101-1105
[9]李进华,张英奎,赵丽娜,等. 2001-2012年河北省主要出生缺陷发生率及变化趋势分析[J].中国妇幼保健,2013,28(29):4767-4771.
[10]李洁,吴军华,邱海燕.宁波市2011-2014年新生儿出生缺陷监测结果分析[J].中国预防医学杂志,2017,18(5):334-340.
[11]谢琼,谭红专,秦家碧,等.湖南省2007-2016年以医院为基础的出生缺陷监测情况分析[J].实用预防医学,2017,24(9):1031-1036.
[12]李武鸣.辽宁省2010年-2014年围产儿出生缺陷检测结果分析[J].中国优生与遗传杂志,2017,25(5):98-99.
[13]张霆,王芳,林良明,等.中国出生缺陷高发地区不同监测时段结构性出生缺陷发生率的比较分析[J].中华流行病学杂志,2008,29(3):220-223.
[14] Luquetti DV,Leoncini E,Mastroiacovo P. Microtiaanotia:a global review of prevalence rates[J]. Birth Defects Res A Clin Mol Teratol, 2011, 91(9):813-822.
[15] Antoszewski B,Fijakowska M. The prevalence of cleft lip and/or palate in children from Lodz between years1981-2010[S]. Congenit Anom(Kyoto)2015,doi:10. 1111/cga. 12133.[Epub ahead of print]
[16] Bedard T,Lowry RB,Sibbald B,et al. Congenital limb deficiencies in Alberta-a review of 33 years(1980-2012)from the Alberta Congenital Anomalies Surveillance System(ACASS)[J]. Am J Med Genet A,2015,167(11):2599-2609.
[17] Cervellione RM,Mantovani A,Gearhart J,et al. Prospective study on the incidence of bladder/cloacal exstrophy and epispadias in Europe[J]. J Pediatr Urol,2015,pii:S1477-5131(15)00269-7.
[18] Deng C,Yi L,Mu Y,et al. Recent trends in the birth prevalence of Down syndrome in China:impact of prenatal diagnosis and subsequent terminations[J]. Prenat Diagn,2015,35(4):311-318.
[19] Jalilevand N,Jalaie S. Prevalence of cleft lip and palate among four provinces in the West and North-West of Iran[J]. J Res Med Sci,2015,20(6):548-553.
[20] Marshall J,Salemi JL,Tanner JP,et al. Prevalence,Correlates,and Outcomes of Omphalocele in the United States,1995-2005[J]. Obstet Gynecol,2015,126(2):284-293.
[21] McGivern MR,Best KE,Rankin J,et al. Epidemiology of congenital diaphragmatic hernia in Europe:a registerbased study[J]. Arch Dis Child Fetal Neonatal Ed,2015,100(2):F137-144.
[22] Schneider A,Blanc S,Bonnard A,et al. Results from the French National Esophageal Atresia register:oneyear outcome[J]. Orphanet J Rare Dis,2014,9:206.
[23] Vo LU,Langlois PH. Time trends in prevalence of gastroschisis in Texas,1999 to 2011:Subgroup analyses by maternal and infant characteristics[J]. Birth Defects Res A Clin Mol Teratol,2015,103(11):928-940.
[24] Takahashi D,Hiroma T,Takamizawa S,et al. Population-based study of esophageal and small intestinal atresia/stenosis[J]. Pediatr Int,2014,56(6):838-844.
[25] Xiaohong Li,Jun Zhu,Yanping Wang,et al. Geographic and urban–rural disparities in the total prevalence of neural tube defects and their subtypes during2006–2008 in China:a study using the hospital-based birth defects surveillance system[J]. BMC Public Health,2013,13:161.
[26] Munch TN,Rasmussen ML,Wohlfahrt J,et al. Risk factors for congenital hydrocephalus:a nationwide,register-based,cohort study[J]. J Neurol Neurosurg Psychiatry,2014,85(11):1253-1259.
[27] Ren AG. Prevention of neural tube defects with folic acid:The Chinese experience[J]. World J Clin Pediatr,2015,4(3):41-44.
[28] Xu LF,Liang CZ,Lipianskaya J,et al. Risk factors for hypospadias in China[J]. Asian J Androl,2014,6(5):778-781.
[29] Wan S,Wang Y,Gu S. Epidemiology of male genital abnormalities:a population study[J]. Pediatrics,2014,133(3):e624-627.
基本信息:
DOI：10.19757/j.cnki.issn1674-7763.2018.06.004
中图分类号:R174
引用信息:
[1]李兵,徐昊立,李玉萍等.2012-2016年广东省21种出生缺陷医院监测发生情况分析[J].中国妇幼卫生杂志,2018,9(06):14-19.DOI:10.19757/j.cnki.issn1674-7763.2018.06.004.
基金信息:
中国疾病预防控制中心妇幼保健中心合生元母婴营养与健康研究项目(2017FYH003);; 广东省医学科学技术研究基金(C2015009)