| 569 | 5 | 384 |
| 下载次数 | 被引频次 | 阅读次数 |
宫颈癌是最常见的妇科恶性肿瘤,严重威胁着女性生命和健康。正常阴道微生态对维持机体稳态具有重要作用,阴道微生态失调与宫颈病变有密切关系。目前对宫颈癌患者阴道微生态状况研究相对较少,对宫颈癌根治术后及术后放化疗后患者阴道微生态状况研究更是缺乏。本文就宫颈癌患者术前及术后、术后放化疗后阴道微生态状况的最新研究进展进行综述。
Abstract：Cervical cancer is the most common gynecological malignancy,which seriously threatens women's life and health.Normal vaginal microecology plays an important role in maintaining the homeostasis of the body. Vaginal microecology disorder is closely related to cervical lesions. At present,there are few researches on the vaginal microecology of cervical cancer patients,especially after radical resection and postoperative radiotherapy and chemotherapy. This article reviews the latest research progress of vaginal microecology in patients with cervical cancer before and after operation,and postoperative radiotherapy and chemotherapy.
[1] Li H,Wu X,Cheng X. Advances in diagnosis and treatment of metastatic cervical cancer[J]. J Gynecol Oncol,2016,27(4):e43.
[2]李莉.宫颈癌不可怕,预防筛查早诊是关键[J].癌症康复,2018(2):27-29.
[3]崔曼,张婧,刘春艳,等. 968例宫颈高危型HPV感染患者临床分析[J].中国妇幼保健,2016,31(9):1839-1840.
[4]卢玉,赵建武.宫颈高危HPV持续感染与阴道微生态相关性研究进展[J].中国医药导报,2018,15(03):26-29.
[5]商若天,孔为民.宫颈癌同步放化疗患者阴道微生态状况及影响因素分析[J].医学综述,2018,24(10):1947-1951.
[6] Kyrgiou M,Mitra A,Moscicki AB. Does the vaginal microbiota play a role in the development of cervical cancer[J]? Transl Res,2017,179(2):168-182.
[7]马薇.女性一生不同阶段阴道微生态菌群特征研究进展[J].中国实用妇科与产科杂志,2016,14(8):817-820.
[8]肖冰冰.阴道微生态的分子生物学研究[J].中国实用妇科与产科杂志,2017,33(08):795-800.
[9]王跃萍.乳酸菌阴道胶囊纠正阴道炎性后遗症微环境紊乱的疗效研究[J].医药论坛杂志,2015,36(07):70-71.
[10]刘玖玖.阴道微生态与高危型人乳头瘤病毒感染和宫颈病变的相关性研究[J].医药论坛杂志,2017,38(4):88-89.
[11] Abdelmaksoud AA,Koparde VN,Sheth NU,et al. Comparison of lactobacillus crispatus isolates from lactobacillus-dominated vaginal microbiomes with isolates from microbiomes containing bacterial vaginosis associated bacteria[J]. Microbiology-SGM,2016,162(3):466-475.
[12] Melkumyan AR,Priputnevich TV,Ankirskaya A,et al.Effects of antibiotic treatment on the lactobacillus composition of vaginal microbiota[J]. Bulletin of Experimental Biology and Medicine,2015,158(6):766-768.
[13]李慧,马莉,王永霞.宫颈癌患者阴道微生态状况分析[J].现代肿瘤医学,2018,26(02):276-279.
[14]张利利,王伟,郝敏.阴道微生态与人乳头瘤病毒感染[J].妇产与遗传,2017,7(4):41-44.
[15]王鹏程,宋静慧.宫颈病变患者治疗前后阴道微生态变化与HPV感染的关系研究进展[J].中国妇产科临床杂志,2015,16(05):473-475.
[16]王鹏程,宋静慧.高级别子宫颈上皮内病变患者术后阴道微生态与HPV转归的相关性分析[J].中国妇产科临床杂志,2018,19(2):129-131.
[17]赵婧,赵雪楠,任雪慧,等.阴道微环境失衡与HRHPV感染及宫颈病变相关性研究进展[J].世界最新医学信息文摘,2019,19(16):85-86.
[18] Audirac-Chalifour A,Torres-Poveda K,Bahena-Rom6an M,et al. Cervical Mierobiome and Cytokine Profile at Various Stages of Cervical Cancer:A Pilot Study[J].PLo S One,2016,11(4):e0153274. DOI:10. 1371/journa1. pone. 0153274.
[19]关晓梅,王谨言,王艳华,等.阴道微生态与高危型人乳头瘤病毒感染和宫颈病变的关系研究[J].中国微生态学杂志,2017,29(3):347-350.
[20]梁圆.阴道菌群改变与宫颈癌前病变相关性的初步研究[D].大连:大连医科大学学报,2015.
[21]田小英,宋保志,廖秦平,等.妇科恶性肿瘤术后阴道微生态状况分析[J].中国微生态学杂志,2013,25(10):1195-1198.
[22]吴秋萍,叶金艳,程浩,等.宫颈癌术后HPV持续感染者阴道微生态状况分析[J].中国微生态学杂志,2015,27(10):1210-1213.
[23]宋世静,牛战琴.全子宫切除术后阴道微生态状况分析[J].临床医药实践,2015,24(10):731-734.
[24] Haie-Meder C,Morice P,Castiglione M,et al.欧洲肿瘤内科协会对宫颈癌的诊断、治疗和随访所制定的临床实践指南[J].国际妇产科学杂志,2011,38(1):82-84.
[25]饶井芬,李青山,朱彤,等.晚期宫颈癌局部近距离放疗期间医院感染及阴道粘连的临床特点分析[J].中华医院感染学杂志,2018,28(09):1401-1403,1440.
[26]毛佩瑜,蒋学禄.宫颈癌的放射治疗及其对阴道微生态的影响[J].浙江医学,2018,40(17):1990-1992.
[27]张彩霞,苟占彪,车团结,等.宫颈癌患者放疗前后乳酸菌的变化及药敏分析[J].实用预防医学,2015,22(8):1004-1006.
[28]梁旭东,彭二玄,朱思敏,等.化疗对妇科恶性肿瘤患者阴道微环境影响[J].中国妇产科临床杂志,2016,17(5):395-397.
[29]郑爱文,孙海燕,陈雅卿,等.子宫切除术后残端阴道上皮内瘤变临床分析[J].浙江医学,2015,37(01):18-21.
[30]崔丹丹,于秀文,王俊苹,等. HPV持续感染状态对宫颈癌手术预后的影响分析[J].中外女性健康研究,2019(03):96,137.
[31]文政芳,杨君,赵淑珍,等.宫颈癌患者人乳头状瘤病毒感染与阴道菌群及炎性因子变化研究[J].中华医院感染学杂志,2016,26(19):4500-4502.
[32] Wohlmeister D,Vianna DR,Helfer VE,et al. Association of human papillomavirus and chlamydiatrachomatis with intraepithelial alterations in cervix samples[J].Mem Inst Oswaldo Cruz,2016,111:106-113.
[33]伍凤莉,周丹,吕秋波,等.宫颈癌前病变及宫颈癌患者阴道微生态评价[J].中国临床医生杂志,2018,46(11):1344-1346.
基本信息:
DOI：10.19757/j.cnki.issn1674-7763.2019.05.020
中图分类号:R737.33
引用信息:
[1]张晗,林琳,杞朝梅,等.宫颈癌患者阴道微生态研究进展[J].中国妇幼卫生杂志,2019,10(05):91-94.DOI:10.19757/j.cnki.issn1674-7763.2019.05.020.