目的 了解山东省德州市德城区9～45岁女性人乳头瘤病毒（human papilloma virus,HPV）疫苗接种情况，为下一步加速推动消除宫颈癌行动计划提供数据支持。方法 利用山东省免疫规划信息系统收集2017—2022年山东省德州市德城区适龄女性二价、四价、九价HPV疫苗接种信息，分析德城区不同年份、不同年龄段和不同地区适龄女性HPV疫苗接种情况。结果 2017—2022年德城区适龄女性共接种HPV疫苗83 791剂次，其中接种二价HPV疫苗34 345剂次，占总剂次数的40.99%，接种剂次数逐年上升。德城区适龄女性共接种HPV疫苗第一剂32 927剂次，适龄女性人口接种覆盖率为19.02%。其中，9～15岁女性接种覆盖率最低（2.08%）,16～26岁女性接种覆盖率最高（24.31%），两组比较差异有统计学意义（χ2=44.20,P<0.05）。城区、城乡结合部、农村适龄女性接种覆盖率分别为40.55%、6.25%和4.90%，差异有统计学意义（χ2=255.14,P<0.05）。完成HPV疫苗全程接种的人数为21 806人，全程接种率为12.60%。结论 德城区9～45岁适龄女性HPV疫苗总体接种率偏低，应继续加强宫颈癌疾病和HPV疫苗的科普知识宣传及健康教育，提高德城区女性HPV疫苗接种率。9～15岁女性、农村地区和城乡结合部适龄女性接种率较低，应作为健康教育的重点人群和制定政策时重点关注的对象。

Objective To understand the vaccination coverage of human papillomavirus(HPV) among women aged 9-45 years in Decheng District, Dezhou City, Shandong Province and to provide data support for accelerating the elimination of cervical cancer.Methods Utilizing the immunization planning information system of Shandong Province, vaccination information for bivalent,quadrivalent, and 9-valent HPV vaccines among age-appropriate women in Decheng District, Dezhou City, Shandong Province from2017 to 2022 was collected and analyzed. This information was used to assess the HPV vaccination status among age-appropriate women in different years, age groups, and regions of Decheng District. Results A total of 83 791 doses of HPV vaccine were administered in Decheng District from 2017 to 2022, with 32 927 doses being the first dose. The vaccination coverage rate among ageappropriate women was 19.02%. The vaccination coverage rate was highest among women aged 16-26 years(24.31%), while it was the lowest among women aged 9-15 years(2.08%). The vaccination coverage rate of age-appropriate women in urban areas was40.55%, compared to 6.25% in urban-rural fringes and 4.90% in rural areas. The number of women who completed the full vaccination was21 806, and the full vaccination rate was 12.60%. Conclusion The overall HPV vaccination rate among women aged 9-45 years in Decheng District is low. There is a need to continue strengthening public awareness on cervical cancer and HPV vaccines, as well as enhancing health education, to increase the HPV vaccination rate among women in Decheng District. Women aged 9-15 years and women living in rural areas and urban-rural fringes exhibit lower vaccination rates and should be prioritized as key targets for health education and policy interventions.